Saturday, July 20, 2013

Control del tabaco: cuando la economía vence a la salud

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Tobacco control: when economics trumps health

Tobacco makes a lot of people a lot of money. This mantra should be repeated often during any discussion of the epidemic of tobacco use. Today's discussion arises because WHO released a report on the global tobacco epidemic, stating that 2·3 billion people in 2012 were reached by at least one measure to reduce tobacco use, including warning labels, advertising bans, or high taxes. The report shows increases from 2010 in effective communication of the message that tobacco use is bad for health.
Gaps in coverage therefore exist for two-thirds of the world's population. 37 countries do not dissuade cigarette use with suitable taxation, and 130 have minimal or no policies covering use of warning labels. Even in countries with nominal bans and control measures, lax enforcement and corruption eviscerates their effectiveness. Increasing the number of people covered by comprehensive control measures, such as WHO's Framework Convention on Tobacco Control's MPOWER, will need strong political will.
Such political will—especially moves to restrict advertising and sale of tobacco products—is vehemently opposed by the tobacco industry on the grounds of free trade and intellectual property rights. New Zealand's ambitious plan to reduce smoking prevalence to less than 5% by 2025 and Australia's introduction of standardised packaging, which was targeted by cynical legal opposition, have set benchmarks in tobacco control. By contrast, the UK Government's decision to pause the consultation about the introduction of standardised packaging (citing sparse data, economic grounds, and fears of rises in illicit trade) is a disgrace.
Effective strategies and strong leadership are needed to influence those countries without adequate tobacco control measures. What does the UK Government's decision say, if not that economics trumps health? Despite proportional decreases in use, more people worldwide smoke now than ever before and tobacco use still kills more than 6 million every year. The UK should join Australia and New Zealand in setting an example to the countries looking to strengthen their resolve against the tobacco epidemic.

¿Por qué la oncología?

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 The Specialty of Medical Oncology

Artículo de Alok A. Khorana, MD

Why oncology? It's a question that I am often asked -- by trainees, by other physicians, sometimes even by patients or their families. Implicit in this question is the pervasive belief that cancer medicine is a "difficult" specialty. I would like to address this perception and dispel some of the myths about the treatment of cancer.
Oncology as used here refers primarily tomedical oncology, which is a subspecialty of internal medicine. A fellowship in medical oncology typically lasts for 2 or 3 years following a 3-year residency in internal medicine. The 2- or 3-year term is determined by whether you are subspecializing in hematology and oncology (3 years) or oncology alone (2 years). Hematology encompasses benign diseases such as anemia and thromboembolism, as well as a greater emphasis on malignant hematologic disorders and stem cell transplant. Surgical and radiation oncology are separate subspecialties, although many of the issues are applicable across the board to the treatment of patients with cancer. And although my discussion centers broadly on medical oncology, it is quite common (particularly in academic medical centers) for oncologists to subspecialize. The most obvious split is hematology (benign or malignant) and oncology (basically solid tumors), but multiple other areas of focus can be pursued. My own practice and research, for instance, focus on gastrointestinal cancers; similarly, other oncologists focus solely on lung, genitourinary, leukemia, or transplant patients.

So, why oncology? For me, it boils down to 3 reasons. First, it is rewarding. In contrast to the prevailing perception, the subspecialty of oncology is incredibly gratifying. The relationships that you develop with patients and their families are unlike those in almost any other subspecialty. Once a patient has a diagnosis of cancer, the oncologist serves as both a treating provider and a gatekeeper for other providers. We see the patient and his or her family members on a regular basis. As gatekeepers, our role is similar to that of primary care physicians but is much more intense, given the seriousness of the disease and the frequency with which we see our patients in a short time span. To witness the resilience and strength of my patients and their families amid the devastation of a cancer diagnosis and its implications is always a privilege.
The second reason to choose oncology is that it is challenging. The science of oncology is undergoing a major paradigm shift. For the past several decades, chemotherapy has been the backbone of treatment, but most oncologists agree that we appear to have reached the ceiling of what is possible with chemotherapy combinations. In the meantime, our understanding of cancer biology has progressed substantially and this has led to the development of so-called "targeted therapy" -- drugs designed to affect specific targets that are up- or downregulated in malignant cells. Very few actual cures have resulted thus far from the development of targeted agents, so chemotherapy or combinations of chemotherapy and targeted agents are both widely used as we transition from one generation of treatment to the next. Unlike other subspecialties such as cardiology, oncologists have not yet found answers to all or even most of the most common diagnoses. This means that many advances must yet be made, and if you choose oncology, you will be among those making them. Moreover, there are many ways to make those advances: as a basic science researcher working with preclinical models, as a translational investigator finding new biomarkers, as a clinical trialist testing new drugs, or as a health services researcher, finding ways to reduce costs or improve quality.

Finally, oncology changes quickly and constantly. Oncologists respond rapidly to new data; we are a community of early adopters. It is not uncommon for thousands of oncologists to return home on a Tuesday evening in early June and change their treatment plans for Wednesday morning. As next-generation sequencing is becoming cheaper and more usable at the bedside, oncologists are already using tumor mutational status to make decisions in real time about which drugs to use for individual patients. We are at the cusp of the precision medicine revolution.
Now, it's important to be realistic: Oncology isn't for everyone. If you are squeamish about taking care of dying patients or developing close bonds with patients and families; if you find it overwhelming to manage a myriad of symptoms at once; or if you prefer to not have your treatment algorithms change overnight, then oncology might not be for you.
But if you like science and think that it is cool to be able to use genomics at the bedside; if you are not fazed by challenges and losses; if you want to be at the cutting edge of new drug developments; and, above all, if you want to make really sick people better, do I have the right field for you.

Tuesday, June 4, 2013

"Adicción" a los teléfonos inteligentes puede afectar el desarrollo de adolescentes

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SAN FRANCISCO — The greater the overuse of smartphones, the greater the risk for severe psychopathologies in adolescents, new research suggests.
The study of nearly 200 adolescents in Korea showed that those who were very high users of smartphones had significantly more problematic behaviors, including somatic symptoms, attentional deficits, and aggression, than did those who were low users.
In addition, the investigators note that the effects of smartphone overuse were similar to those of Internet overuse. Internet use gaming disorder has been included in Section 3 of the just-released fifth edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5), the section of the manual reserved for conditions considered worthy of further research.
"Regardless of addictive patterns, our results showed that the more addicted that youth were, the more severe their psychopathologies were," study investigator Jonghun Lee, MD, PhD, professor of psychiatry at the Catholic University of Daegu School of Medicine in South Korea, told reporters attending a press briefing here at the the American Psychiatric Association's (APA's) 2013 Annual Meeting.
"The number of adolescents addicted to smartphone use will increase because the popularization of smartphones is an inevitable social trend. And the younger they are, the more vulnerable they are," said Dr. Lee.
Therefore, he said, clinicians should try to screen for smartphone addiction, as well as for Internet or computer addiction, in their adolescent patients.
However, "there is no standardized scale for defining this, so we need to develop it. It's important to identify youth who are at risk to prevent their addiction," Dr. Lee told Medscape Medical News.
Press conference moderator Jeffrey Borenstein, MD, chair of the Council on Communications for the APA, added that "this raises an important opportunity" for clinicians to help their patients.
"The majority of people who have psychiatric illnesses — depression, for example — don't get treatment. I think a part of the puzzle is educating the public, but it's also improved screening," said Dr. Borenstein.
Dramatic Increase in Cell Phone Use
According to a report released by the Pew Research Center last March, 37% of teens in the United States had smartphones in 2012 — up significantly from 23% in 2011. In addition, 95% of all teens use the Internet.
Dr. Lee reported that smartphone use in children and adolescents between the ages of 5 and 19 years in Korea increased dramatically from 7.5% in 2009 to 67% in 2012.
Dr. Jonghun Lee
"There are a wide range of smartphone functions, including Internet use, online gaming, digital cameras, and GPS [Global Positioning System] navigation. And you can use these functions anywhere and at any time. But these various convenient functions are contributing factors to excessive use," he said.
He added that according to the Seoul Metropolitan Office of Education, 6.5% of Korean adolescents have reported that they are affected by excessive use of smartphones.
"This has become a social issue, and they noted that it has negatively affected their studies," said Dr. Lee. In addition, according to the Korean Youth Counseling and Welfare Institute, 41.3% of youth reported excessive gaming, 12% reported abnormal behavior after losing their smartphone, 9.3% reported conflicts with parents, and 9% reported using their smartphone to look at obscene material.
"These are highly predictive of addiction," said Dr. Lee. "Our earlier study showed that using it in particular situations was also associated with smartphone addiction, such as using it when going to bed or in the bathroom."
"Recently, we have also heard that smartphone overuse by youth is associated with depression, more exposure to obscene material, and even suicide."
For the current study, the investigators enrolled 195 adolescents who were questioned using the 2010 Smart-phone Addiction Rating Scale (SARS) and the Young Internet Addiction Scale (YIAS). In addition, the Korea–Youth Self Report (K-YSR) was used to assess possible psychopathologies, including somatic symptoms, attention problems, and aggression.
Results showed that total problematic behavior scores on the K-YSR were significantly correlated with both the total SARS (P < .001) and YIAS (P < .001) scores.
In post hoc analyses, the participants were divided into 4 subgroups: low Internet/low smartphone (low-low) users, high Internet/high smartphone (high-high) users, low Internet/high smartphone (low-high) users, and high Internet/low smartphone (high-low) users.
The low-low group had significantly lower scores than the other 3 groups on total problematic behaviors and internalizing problems (P < .01 for all), and that group had significantly fewer externalizing problems than the high-high group (P < .01).
In addition, there was a significant difference among the groups on 7 other subscales of the K-YSR, including withdrawal (P < .05), somatic symptoms (P < .01), and thought problems (P < .01), as well as depression/anxiety, attention problems, delinquency, and aggression (all, P < .001).
The investigators add that the number of adolescents affected is likely to increase as smartphones become more and more popular.
Intervene When Necessary
"I would say that parents and clinicians should have concern if smartphones affect the functioning of the child, including at school and interacting socially with friends and family," Dr. Borenstein told Medscape Medical News.
Dr. Jeffrey Borenstein
"If there really begins to be some effects in functioning, that's when I would have a concern and want to look further into it." He added that clinicians should also advise parents that they are responsible and in charge and that, although it might be difficult, they need to establish a set of rules for use.
"These will be a little different for each family. But certainly if the use of the Internet or smartphones is getting in the way of the functioning of the child, the parent needs to intervene," he said.
Dr. Borenstein, who is also president and CEO of Brain and Behavior Research, was not involved with this study.
He noted that "we're really just beginning to study these issues" with regard to causal effects between Internet and smartphone addictions and subsequent psychopathologies.
"That's why this study is such an important one. But it's hard to tease out the chicken and the egg off it. So finding an association is useful. It says: 'Okay, there's something here to be concerned about. So let's investigate it further,'" said Dr. Borenstein.
"Probably if we tease it out we'll find that for some people, that association is a cause and effect, and for others...it may be that something else was going on that resulted in them being on the Internet. But more work needs to be done."
The study authors and Dr. Borenstein did not disclose any relevant financial relationships.
The American Psychiatric Association's 2013 Annual Meeting. Abstract NR6-41. Presented May 19, 2013.

Friday, May 31, 2013

Bienvenidos a Dalmed Blog

Estos últimos años Dalmed Ecuador ha crecido significativamente, y queríamos hacer algo para estar mucho más cerca de nuestros clientes, contactos y amigos médicos

¡Bienvenido a nuestro Blog! Nuestra intención es compartir con ustedes información científica, novedades tecnológicas y notas curiosas que pensamos que pueden ser de interés para nuestros amigos médicos más cercanos.

Nosotros no somos un centro de investigación, pero sí somos muy curiosos e interesados en los avances de la medicina, por lo que publicaremos información de interés, pero también de fuentes muy confiables.

Mucha de la información que publicaremos se encuentra en inglés. A la derecha de esta página encontrarás un traductor que te ayudará a traducir todo el contenido en el caso de que lo necesites.

Te invitamos a que nos visites regularmente y nos escribas si deseas información sobre algún tema en particular.

De nuevo... ¡Bienvenido!